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GTT Adipocytes size distributions: mathematical model of a tissue property. 

5 février @ 17h00 - 18h00

Pour le GTT de cette semaine, nous vous donnons rendez-vous ce mercredi 5 février à 17h.
Nous aurons le plaisir d’écouter Aloïs Dauger 
(LJLL) nous parler de son travail : Adipocytes size distributions: mathematical model of a tissue property. 
 
L’exposé aura lieu en salle de séminaire, dans la limite des places disponibles, et sera aussi retransmis sur BigBlueButton au lien suivant:
https://orsay.bbb.cnrs.fr/b/qis-pcx-qqd-1i9 

Voici l’abstract de l’exposé :

Obesity is nowadays a global public health issue. It is defined as an excess of lipids stored that harms health. The white adipose tissue is in charge of this storage via its main cells: adipocytes. These cells present a singular property: their size varies from 10 micro meter up to 200 micro meter of diameter (which implies a large volume variation). In addition the observed size distribution is bimodal, presenting 2 characteristic sizes. A previous mathematical model (made of ODE) provided size distribution bimodality.  Also in the previous model, bimodality was considered a consequence of a bi-stable distribution of  cell sizes at equilibrium: meaning that adipocytes had to have two stable sizes. In this work,  we show that bi-stable cells population cannot generate realistic size distributions. Indeed, we reproduced size distribution data with mono-stable cells (i.e. with one equilibrium size). We thus show that bimodality of adipose tissue size distribution does not arise directly from cellular bi-stability but rather from a tissue property. Results from adipogenesis modelling to reproduce the tissue reaction to lipid addition shall be presented and discussed.

Et nous vous donnons bien sûr rendez-vous dès 16h30 pour le GTThé!

Bonne semaine!
La GTTeam
Antonin, Siguang, Soré

 
PS : si vous souhaitez vous inscrire/désinscrire de la liste, vous pouvez suivre le lien https://listes.sorbonne-universite.fr/sympa/info/sciences-ljll-gdt-thesards



[French au dessus]

Greetings,

This week’s GTT will take place this Wednesday (February 5th) at 5pm.
We will have the pleasure of listening to Aloïs Dauger (LJLL) who will present his work on: 
Adipocytes size distributions: mathematical model of a tissue property. 

The talk will take place in the seminar room, and will also be available on BigBlueButton, at the following link:
https://orsay.bbb.cnrs.fr/b/qis-pcx-qqd-1i9 

The abstract of the talk is the following:

Obesity is nowadays a global public health issue. It is defined as an excess of lipids stored that harms health. The white adipose tissue is in charge of this storage via its main cells: adipocytes. These cells present a singular property: their size varies from 10 micro meter up to 200 micro meter of diameter (which implies a large volume variation). In addition the observed size distribution is bimodal, presenting 2 characteristic sizes. A previous mathematical model (made of ODE) provided size distribution bimodality.  Also in the previous model, bimodality was considered a consequence of a bi-stable distribution of  cell sizes at equilibrium: meaning that adipocytes had to have two stable sizes. In this work,  we show that bi-stable cells population cannot generate realistic size distributions. Indeed, we reproduced size distribution data with mono-stable cells (i.e. with one equilibrium size). We thus show that bimodality of adipose tissue size distribution does not arise directly from cellular bi-stability but rather from a tissue property. Results from adipogenesis modelling to reproduce the tissue reaction to lipid addition shall be presented and discussed.


And we’ll meet as soon as 4:30pm for the GTTea!

Have a nice week!
The GTTeam
Antonin, Siguang, Soré

PS: If you wish to subscribe/unsubscribe, please use https://listes.sorbonne-universite.fr/sympa/info/sciences-ljll-gdt-thesards

Details

Date:
5 février
Time:
17h00 - 18h00
Event Category:

Venue

SU – 15-16-309
4 Place Jussieu
Paris, 75005 France
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Other

Orateur
Aloïs Dauger (LJLL)