Pour le GTT de cette semaine, nous vous donnons rendez-vous ce mercredi 5 février à 17h.
Nous aurons le plaisir d’écouter Aloïs Dauger (LJLL) nous parler de son travail : Adipocytes size distributions: mathematical model of a tissue property.
Voici l’abstract de l’exposé :
Obesity is nowadays a global public health issue. It is defined as an excess of lipids stored that harms health. The white adipose tissue is in charge of this storage via its main cells: adipocytes. These cells present a singular property: their size varies from 10 micro meter up to 200 micro meter of diameter (which implies a large volume variation). In addition the observed size distribution is bimodal, presenting 2 characteristic sizes. A previous mathematical model (made of ODE) provided size distribution bimodality. Also in the previous model, bimodality was considered a consequence of a bi-stable distribution of cell sizes at equilibrium: meaning that adipocytes had to have two stable sizes. In this work, we show that bi-stable cells population cannot generate realistic size distributions. Indeed, we reproduced size distribution data with mono-stable cells (i.e. with one equilibrium size). We thus show that bimodality of adipose tissue size distribution does not arise directly from cellular bi-stability but rather from a tissue property. Results from adipogenesis modelling to reproduce the tissue reaction to lipid addition shall be presented and discussed.
Et nous vous donnons bien sûr rendez-vous dès 16h30 pour le GTThé!
Bonne semaine!
La GTTeam
Antonin, Siguang, Soré
[French au dessus]
Greetings,
This week’s GTT will take place this Wednesday (February 5th) at 5pm.
We will have the pleasure of listening to Aloïs Dauger (LJLL) who will present his work on: Adipocytes size distributions: mathematical model of a tissue property.
The talk will take place in the seminar room, and will also be available on BigBlueButton, at the following link:
Obesity is nowadays a global public health issue. It is defined as an excess of lipids stored that harms health. The white adipose tissue is in charge of this storage via its main cells: adipocytes. These cells present a singular property: their size varies from 10 micro meter up to 200 micro meter of diameter (which implies a large volume variation). In addition the observed size distribution is bimodal, presenting 2 characteristic sizes. A previous mathematical model (made of ODE) provided size distribution bimodality. Also in the previous model, bimodality was considered a consequence of a bi-stable distribution of cell sizes at equilibrium: meaning that adipocytes had to have two stable sizes. In this work, we show that bi-stable cells population cannot generate realistic size distributions. Indeed, we reproduced size distribution data with mono-stable cells (i.e. with one equilibrium size). We thus show that bimodality of adipose tissue size distribution does not arise directly from cellular bi-stability but rather from a tissue property. Results from adipogenesis modelling to reproduce the tissue reaction to lipid addition shall be presented and discussed.
And we’ll meet as soon as 4:30pm for the GTTea!
Have a nice week!
The GTTeam
Antonin, Siguang, Soré